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A recent study revealed structural differences between the binding of FOXO1 and FOXO3 phosphorylated at S256 or S253, respectively to 14-3-3 chaperone proteins, providing evidence for isoform-specific binding of FOXO proteins to 14-3-3 [37]

While suggestive of a treatment signal, the result did not reach statistical significance

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Furthermore, ACE rapidly increased ROS levels and inhibited GPX enzyme activity, indicating that ACE, like RSL3, may bind directly to GPX4 (Fig

Although a second application of CNO failed to induce a second increase in Ca 2+ in half of the responsive ND neurons, in ND neurons that exhibited a second response to CNO, PPADS reduced the peak area of the CNO-induced Ca 2+ rise by 53%, supporting the idea of ATP-mediated signalling from GLUTag cells to neurons (Fig